Stem cell competition: finding balance in the niche

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Stem cell competition: finding balance in the niche

Trends in Cell Biology, Publication Date 16 April 2013
Copyright © 2013 Elsevier Ltd All rights reserved.
DOI: 10.1016/j.tcb.2013.03.001

Rachel R. Stine

Erika L. Matunis

Department of Cell Biology, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA

Adult stem cells reside in local microenvironments (niches) that produce signals regulating the outcome of stem cell divisions and stem cell–niche interactions. Limited space and signals in the niche often force stem cells to compete with one another. Although previous studies have uncovered several examples of genetically distinct stem cells competing for niche access, recent studies demonstrate that genetically equivalent stem cells compete under normal conditions, resulting in dynamic stem cell behavior in the niche. New work in multiple vertebrate and invertebrate tissues shows that stem cell competition occurs continuously and mutations disrupting the balance between competing stem cells can cause diseases and defects in the niche. This review discusses recent insights into stem cell competition in mammals and Drosophila.

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