Histone modifications and mitosis: countermarks, landmarks, and bookmarks

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Histone modifications and mitosis: countermarks, landmarks, and bookmarks

Trends in Cell Biology, Volume 23, Issue 4, Pages 175-184, Publication Date 14 December 2012
Copyright © 2012 Elsevier Ltd All rights reserved.
DOI: 10.1016/j.tcb.2012.11.005

Fangwei Wang

Jonathan M.G. Higgins

Life Sciences Institute, Zhejiang University, Hangzhou, Zhejiang 310058, China

Division of Rheumatology, Immunology and Allergy, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, USA

The roles of post-translational histone modifications in regulating transcription and DNA damage have been widely studied and discussed. Although mitotic histone marks, particularly phosphorylation, were discovered four decades ago, their roles in mitosis have been outlined only in the past few years. Here we aim to provide an integrated view of how histone modifications act as ‘countermarks’, ‘landmarks’, and ‘bookmarks’ to displace, recruit, and ‘remember’ the location of regulatory proteins during and shortly after mitosis. These capabilities allow histone marks to help downregulate interphase functions such as transcription during mitosis, to facilitate chromatin events required to accomplish chromosome segregation, and to contribute to the maintenance of epigenetic states through mitosis.

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