Quality control mechanisms during ribosome maturation

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Quality control mechanisms during ribosome maturation

Trends in Cell Biology, Volume 23, Issue 5, Pages 242-250, Publication Date 01 February 2013
Copyright © 2013 Elsevier Ltd All rights reserved.
DOI: 10.1016/j.tcb.2013.01.004

Katrin Karbstein

Department of Cancer Biology, The Scripps Research Institute, 130 Scripps Way #2C2, Jupiter, FL 33458, USA

Protein synthesis on ribosomes is carefully quality-controlled to ensure the faithful transmission of genetic information from mRNA to protein. Many of these mechanisms rely on communication between distant sites on the ribosomes, and thus on the integrity of the ribosome structure. Furthermore, haploinsufficiency of ribosomal proteins, which increases the chances of forming incompletely assembled ribosomes, can predispose to cancer. Finally, release of inactive ribosomes into the translating pool will lead to their degradation together with the degradation of the bound mRNA. Together, these findings suggest that quality control mechanisms must be in place to survey nascent ribosomes and ensure their functionality. This review gives an account of these mechanisms as currently known.

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