Hsp90@chromatin.nucleus: an emerging hub of a networker

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Hsp90@chromatin.nucleus: an emerging hub of a networker

Trends in Cell Biology, Volume 23, Issue 4, Pages 193-201, Publication Date 01 January 2013
Copyright © 2012 Elsevier Ltd All rights reserved.
DOI: 10.1016/j.tcb.2012.11.007

Ritwick Sawarkar

Renato Paro

Department of Biosystems Science and Engineering, ETH Zürich, Mattenstrasse 26, 4058 Basel, Switzerland

Faculty of Science, University of Basel, Klingelbergstrasse 50, 4056 Basel, Switzerland

The molecular chaperone heat-shock protein of 90 kDa (Hsp90) stabilizes various proteins and occupies a central position in cellular networks. Hsp90 inhibitors are being tested in clinical trials as anticancer drugs. Recent studies have illuminated the unappreciated significance of this chaperone in chromatin transactions and this review focuses on its role in gene expression. By comparing the different mechanisms by which Hsp90 orchestrates transcriptional regulation, the review outlines the contributions of this function to the cellular and organismal phenotype. We chart exciting avenues for research to gain comprehensive insights in the chaperone's importance in cellular physiology, thereby presenting novel opportunities for therapeutic intervention.

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