Endosomal crosstalk: meeting points for signaling pathways

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Endosomal crosstalk: meeting points for signaling pathways

Trends in Cell Biology, Volume 22, Issue 9, Pages 447-456, Publication Date 16 July 2012
Copyright © 2012 Elsevier Ltd All rights reserved.
DOI: 10.1016/j.tcb.2012.06.004

Máté Pálfy

Attila Reményi

Tamás Korcsmáros

Department of Genetics, Eötvös Loránd University, Pázmány P. s. 1/C, Budapest, H-1117, Hungary

Department of Biochemistry, Eötvös Loránd University, Pázmány P. s. 1/C, Budapest, H-1117, Hungary

Department of Medical Chemistry, Semmelweis University, Tuzoltó u. 37-47, Budapest, H-1094, Hungary

Endocytosis participates in downregulating incoming signals, but ‘signaling endosomes’ may also serve as physical platforms for crosstalk between signaling pathways. Here, we briefly review the role of endosomes in signaling crosstalk and suggest that endosome-associated scaffold proteins mediate this crosstalk. In addition, using a proteome-wide in silico approach – in which we analyze endosome-binding properties and the capacity of candidates to recruit signaling proteins from more than one distinct pathway – we extend the list of putative crosstalk-mediating endosomal scaffolds. Because endosomal crosstalk may be an important systems-level regulator of pathway communication, scaffold proteins that mediate this crosstalk could be potential targets for pharmacological intervention and synthetic engineering.

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