Exam Tips, Certification Exam Guides, Microsoft Exam Tips, CISCO Exam Tips

Tuesday, 18 June 2013

Ricin Deadly, but Not an Effective WMD

Earn Free CME Credits by reading the latest medical news in your specialty.

By Kristina Fiore, Staff Writer, MedPage Today

It may have been a preferred tool of Soviet hit men, but ricin generally flops as a weapon of mass destruction, several bioterrorism experts told MedPage Today.

The toxin, which is derived from castor beans, is most deadly when inhaled or injected, but there are several challenges to spreading it widely enough to inflict damage.

"Ricin for a while was considered to be a weapon of mass destruction (WMD), but the current thinking is that it's hard to disseminate over large populations and it's not contagious person-to-person," said Robert Emery, DrPH, of the University of Texas Health Science Center at Houston.

The poison is the focus of national attention because ricin-laced letters were sent to President Barack Obama and at least one U.S. Senator just days after a bombing at the Boston Marathon.

But even just a small amount can be highly toxic, especially if inhaled or injected, Emery said, and there is no antidote. Breathing in a dose of 240 to 400 mcg can be lethal, and it takes less than that to do major damage if injected.

Bulgarian dissident Georgi Markov, a BBC journalist and critic of the Bulgarian regime who had defected to England, learned that the hard way in 1978 when a suspected KGB agent poked him with an umbrella laden with an injection of ricin.

Markov was dead within 3 days. "It’s more effectively used against an individual target,” Steven Marcus, MD, professor of preventive medicine and community health at New Jersey Medical School, told MedPage Today.

Experts cite this as the lone confirmed fatal case of ricin poisoning, and of other attempts to use ricin as an agent of terror, none have died and few have even become sick, according to Eric Toner, MD, of the Center for Biosecurity at the University of Pittsburgh Medical Center.

That may have something to do with the quality of the product, Toner said. Even though it can be made in a kitchen -- Emery said it is known as the "poor man's toxin" -- by cooking castor beans and using a solvent to extract the ricin, it's not necessarily pure or concentrated.

"It's not usually like what was used against Markhov, which was produced by a sophisticated government lab and very different from being home-brewed," Toner told MedPage Today.

Experts say ricin is less lethal if ingested, but it can still cause damage, and eating enough castor beans can make patients sick -- usually with terrible bouts of diarrhea -- or kill them.

Castor oil used to be one of the most common laxatives, Toner noted, even though it doesn't contain any significant amount of ricin.

Few of the experts contacted by MedPage Today were concerned about cutaneous exposure, which would be the likeliest form among those working in Washington mailrooms. Toner said the powdery substance probably wouldn't have been potent enough to do any damage had it made contact with skin.

"I suspect the perpetrators know that," he said. "It's a very effective way to draw attention and cause havoc, but a very ineffective way to kill someone."

It can't compare to a real WMD like anthrax, he noted, which is easier to disperse and far more fatal.

Ricin blocks protein synthesis at the cellular level and can wreak havoc on nearly all organs. Symptoms manifest anywhere from 4 to 24 hours after exposure, and vary via route of exposure. Those who have inhaled it usually have difficulty breathing, cough, tightness in the chest, and fever.

Because there is no antidote, clinicians can only provide best supportive care while waiting for the toxin to clear, according to Lewis Nelson, MD, an emergency physician at NYU Langone Medical Center. That includes IV fluids as well as mechanical ventilation and renal support if needed.

Though wide dissemination remains a challenge, Nelson said major metropolitan areas like New York would be about as prepared for a ricin attack as they would be for a pandemic flu.

"If you looked at someone with ricin poisoning, you couldn't distinguish it from a major infection," he said. "You just have to try to keep the patient alive until the toxin clears and the organs recover."

With the exception of those who specialize in emergency medicine, doctors receive little training in not only treatment of ricin poisoning, but bioterrorism in general, according to Ken Spaeth, MD, MPH, director of occupational and environmental medicine at North Shore Long Island Jewish Health System on Long Island.

"Relatively little is taught about ricin and ... other biological weapons such as anthrax and smallpox," Spaeth told MedPage Today. "Education regarding chemical and radiological weapons is even more deficient."

He added that recent surveys show most physicians feel unprepared to care for patients exposed to biological, chemical, or radiological weapons.

But Toner noted that information from the CDC on bioterrorism and how to manage these situations is easily available online.

Emery also noted that the U.S. appears to be interested in trying to develop a preventive ricin vaccine, even though attempts at an antidote have failed.

It's not clear whether the ricin-laced letters were connected to the Boston Marathon bombing, but Toner pointed out that since the first letter was received yesterday -- only a day after the bombing -- it's likely the letters were in the mail before the bombs were placed.

"It's either a coincidence, part of a larger plan, or someone has much better mail service than I do," he joked.

UPDATE: This article, originally published on April 17, 2013 at 5:58 p.m., was updated with new material on April 18, 2013 at 1:27 p.m.

Kristina Fiore

Staff Writer

Kristina Fiore joined MedPage Today after earning a degree in science, health, and environmental reporting from NYU. She's had bylines in newspapers and trade and consumer magazines including Newsday, ABC News, New Jersey Monthly, and Earth Magazine. At MedPage Today, she reports with a focus on diabetes, nutrition, and addiction medicine.

Biomarker for Asbestos-Linked Cancer Works (CME/CE)

Earn Free CME Credits by reading the latest medical news
in your specialty.

By Michael Smith, North American Correspondent, MedPage Today Reviewed by Zalman S. Agus, MD; Emeritus Professor, Perelman School of Medicine at the University of Pennsylvania and Dorothy Caputo, MA, BSN, RN, Nurse PlannerThis study suggests that plasma fibulin-3 levels can distinguish healthy persons with exposure to asbestos from patients with mesothelioma.The study also suggests that in conjunction with effusion fibulin-3 levels, plasma fibulin-3 levels can differentiate mesothelioma effusions from other malignant and benign effusions.

Glycoprotein fibulin-3 can be used to identify patients with pleural mesothelioma and may be a useful biomarker for the asbestos-related illness, researchers reported.

Plasma levels of the protein were higher in people with the disease than they were in people exposed to asbestos but who did not have mesothelioma, according to Harvey Pass, MD, of New York University Langone Medical Center in New York City, and colleagues.

And levels in effusions from mesothelioma patients were higher than they were in patients with effusions from other causes, Pass and colleagues reported in the Oct. 11 issue of the New England Journal of Medicine.

On the other hand, the researchers cautioned, it's too early to say that the protein can be used for early detection because of a lack of prospective longitudinal studies.

Despite advances in therapy, median survival for pleural mesothelioma remains about a year from diagnosis, the researchers noted.

Earlier detection might help, but "is limited by the long latency period, an inability of imaging to detect the disease at an early stage even when it is used as a screening strategy, and the lack of sensitive and specific blood-based markers."

The latter gap, they hypothesized, might be filled by fibulin-3 if it could be shown to be a "robust biomarker."

To test the idea, they measured fibulin-3 levels in stored plasma samples from 92 patients with mesothelioma, 136 people exposed to asbestos but who did not have the disease, 93 patients with effusions not caused by mesothelioma, and 43 healthy controls.

They also measured levels in stored effusions from 74 patients with mesothelioma, 39 with benign effusions, and 54 with malignant effusions not caused by mesothelioma. Some participants had both types of samples.

The stored samples were collected in Detroit from 1998 through 2005 and in New York from 2005 through 2011, Pass and colleagues reported.

The researchers also conducted two validation analyses – one each using serum and plasma from mesothelioma patients and cancer-free people with asbestos exposure.

Plasma fibulin-3 levels did not vary according to age, sex, duration of asbestos exposure, or degree of radiographic changes.

On the other hand, they were significantly higher in patients with pleural mesothelioma than in asbestos-exposed people without the disease. In the Detroit cohort, mesothelioma patients averaged 105 nanograms per ml of plasma, compared with 13.9 among the asbestos-exposed controls (P<0.001) and in the New York cohort, the respective averages were 112.9 and 24.3 nanograms per ml (P<0.001).

The same was true for fibulin-3 levels in effusions.

In the Detroit cohort, effusion levels averaged 694.4 nanograms per ml higher in patients with pleural mesothelioma and 211.5 in patients with effusion from other causes. In the New York cohort, the respective averages were 636.4 and 150.6 nanograms per milliliter. Both differences were, again, significant at P<0.001.

In the validation study using serum, fibulin-3 levels were unable to discriminate between patients with mesothelioma and those exposed to asbestos but cancer-free, Pass and colleagues reported.

One possible explanation is that the samples, which were collected from 1985 through 1996 during the Carotene and Retinol Efficacy Trial, might have degraded over time, they suggested.

In the other validation study, a set of plasma samples from the University of Toronto showed lower levels in both patients and asbestos-exposed controls than either of the American cohorts – 66.4 and 13.9 nanograms per milliliter, respectively.

But, Pass and colleagues reported, the difference remained significant at P<0.001.

In an overall comparison of patients with and without mesothelioma, the researchers reported, the receiver-operating-characteristic curve for plasma fibulin-3 levels had a sensitivity of 96.7% and a specificity of 95.5% at a cutoff value of 52.8 nanograms per milliliter.

While more research is needed, they concluded, plasma fibulin-3 levels can help tell people with mesothelioma from those who remain healthy after exposure to asbestos.

Together with levels in effusions, plasma fibulin-3 can also differentiate mesothelioma effusions from other malignant and benign effusions, they argued.

The study had support from the Princess Margaret Hospital Foundation, the Princess Margaret Hospital Mesothelioma Research Program (funded by the Masters Insulators Association of Ontario, International Association of Heat and Frost Insulators and Asbestos Workers, Local 793, and other unions, and the Imperial Oil Charitable Foundation), the M. Qasim Choksi Chair in Lung Cancer Translational Research, the Alan B. Brown Chair in Molecular Genetics, the Ontario Ministry of Health and Long-Term Care, Belluck and Fox, the Simmons Foundation, Levi Phillips and Konigsberg, the Stephen E. Banner Fund for Lung Cancer Research, the Rosenwald Family, the Anderson Family, and the NIH.

Pass reported fnancial links with Champions Oncology, Rosetta Genomics, Pinpoint Genomcs, and SomaLogic.

Michael Smith

North American Correspondent

North American Correspondent for MedPage Today, is a three-time winner of the Science and Society Journalism Award of the Canadian Science Writers' Association. After working for newspapers in several parts of Canada, he was the science writer for the Toronto Star before becoming a freelancer in 1994. His byline has appeared in New Scientist, Science, the Globe and Mail, United Press International, Toronto Life, Canadian Business, the Toronto Star, Marketing Computers, and many others. He is based in Toronto, and when not transforming dense science into compelling prose he can usually be found sailing.

Old Biomarker May Have New Role in Lung Ca (CME/CE)

Earn Free CME Credits by reading the latest medical news
in your specialty.

By Kathleen Struck, Senior Editor, MedPage Today Reviewed by Zalman S. Agus, MD; Emeritus Professor, Perelman School of Medicine at the University of Pennsylvania and Dorothy Caputo, MA, BSN, RN, Nurse PlannerNote that this study was published as an abstract and presented at a conference. These data and conclusions should be considered to be preliminary until published in a peer-reviewed journal.Smokers with low bilirubin levels were at increased risk for lung cancer incidence and mortality compared with those who had the highest bilirubin levels, suggesting that serum bilirubin may be able to function as a potential biomarker for lung cancer risk prediction.

WASHINGTON -- Bilirubin, which is considered a useful liver function marker, may also point to smokers at increased risk for lung cancer.

In a large Taiwanese prospective cohort, male smokers with bilirubin in the lowest quartile lowest had a 69% higher risk for developing lung cancer, and a 76% higher rate of lung cancer mortality, compared with male smokers who had the highest bilirubin levels, said Xifeng Wu, MD, of the University of Texas MD Anderson Cancer Center in Houston.

In men who had never smoked, bilirubin levels had no significant effect on health outcomes.

The research showed that serum bilirubin is a potential biomarker for lung cancer risk prediction, Wu told MedPage Today at the annual meeting of the American Association for Cancer Research.

"It was kind of a surprise and very interesting," Wu said. "The biomarker was identified from metabolic profiling and validated by the large, cohort study."

In the Taiwanese cohort of 435,985 individuals, the incidence rate of lung cancer in men with bilirubin levels of 0.68 mg/dL or less was 7.02 per 10,000 person-years irrespective of smoking history. This compared with a rate of 3.73 per 10,000 person-years in men whose bilirubin levels were 1.12 mg/dL or more, again irrespective of smoking history.

Wu said this translated into a 51% increase in the risk for developing lung cancer for low-bilirubin patients.

Also, the lung-cancer specific mortality rate in men with low bilirubin was 4.84 per 10,000 person-years compared with 2.46 per 10,000 person-years in men with high bilirubin.

When only male smokers were analyzed the associations were starker -- a 76% increase in lung cancer mortality.

Wu said she first conducted global, unbiased metabolomic profiling in serum samples from 20 healthy controls, 20 patients in early-stage lung cancer, and 20 patients in late-stage lung cancer. Matching for age and gender, Wu selected three differentially expressed metabolites for validation in two case-control populations. Bilirubin emerged and was validated by the large Taiwanese prospective cohort.

Wu said the study focused on male smokers and was limited by an insufficient amount of female smokers from which to draw conclusions.

But the research does point to the potential benefit of using biomarkers in cancer research, she said.

"We need to identify additional biomarkers, including metabolomic biomarkers," Wu said.

"It's a very large study and brings up interesting findings that to my knowledge haven't been reported before," said Lecia Sequist, MD, of Massachusetts General Hospital in Boston. "This will generate a lot of interesting future research in biologic relations between bilirubin and lung cancer."

The authors had no disclosures.

Primary source: American Association for Cancer Research
Source reference:
Wu X, et al "Metabolomic profiling identifies bilirubin as a novel serum marker for lung cancer" AACR 2013; Abstract LB-27.

Kathleen Struck

Senior Editor

Kathleen Struck joined MedPage Today after serving as Managing Editor for EverydayHealth.com, Stars and Stripes and MediaNews Group. She lived and traveled internationally for more than 15 years and has written and edited for publications including, Washington Post, Baltimore Sun, Newsday and Regulatory Affairs Professional Society. At MedPage Today, she reports and edits on general news and information.

Boston Bombing: Finding Evidence in the ER

Earn Free CME Credits by reading the latest medical news in your specialty.

By Kathleen Struck, Senior Editor, MedPage Today

BOSTON -- In the aftermath of Monday's marathon bombing, emergency physicians here are tasked not only with saving lives but also saving evidence.

The challenges posed by that dual charge are daunting, but not impossible said Louis Alarcon, MD, of University of Pittsburgh Medical Center.

"We collaborate closely with forensic pathologists and law enforcement," said Alarcon, medical director of trauma surgery. "Our first priority is to save the patient's life -- life and limb over everything. Once we achieve those goals, we also have a strong duty to the evidence."

Oscar Guillamondegui, MD, of Vanderbilt Multidisciplinary Traumatic Brain Injury Clinic in Nashville, said that after treating the victim, "the next step would be to identify if there are foreign bodies, and in the case of a blast event, such as in Boston, that would be the shrapnel that remains within the tissue."

That ‘evidence’ should then be handled as any pathology specimen from a patient: It would be collected in the appropriate container, sealed, documented in the chain-of-command paperwork and sent to a pathologist who turns it over to the appropriate authorities, he said.

At Tufts Medical Center in Boston after Monday's marathon bombing, doctors worked with law enforcement to collect and save fragments of shrapnel that became projectiles with the force of the bombing, Robert Osgood, MD, told Boston's WBUR-FM.

Emergency physicians painstakingly search for bullets, metal, wood, plastic, or other substances that become projectiles in bombings or other events, Alarcon said. His hospital formalized that search with a standard process for evidence collection and preservation, a process so granular that it stipulates when plastic versus metal instruments should be used for collection

"You don't want to deform the object," Alarcon said explaining that plastic or rubber instruments are used when extracting metal fragments.

Once collected the evidence is wrapped in gauze, placed in sterile containers, and given an identifying lab number. The chain of custody is identified by carefully notating every person who comes in contact with the samples, he said.

The transfer of evidence from doctors to police is handled by the hospital's security staff, Alarcon said.

At Brookdale Hospital Medical Center in Brooklyn, N.Y., where roughly 300 patients are treated in the emergency department daily, the police typically oversee evidence collection, said Lewis Marshall Jr., MD, disaster medicine specialist.

But here, too, the bullets are carefully catalogued, photographed, bagged, and then re-bagged before being catalogued by the hospital's pathology department -- all before transfer to authorities.

"It should not be that the emergency room doctor takes the bullet and hands it to the police officer," he said.

"A bombing is a crime scene. We need to train people to understand that so if we prosecute the person who perpetrated the crime -- if we find that person -- the case will stand up in a court of law," Marshall said.

Kathleen Struck

Senior Editor

Saturday, 1 June 2013

HP Launches Exciting All-New Consumer PC Lineup

Today, HP announced its new lineup of consumer notebooks, from an 11-inch touchscreen all the way up to its high-end ENVY 17 models. Some of the new systems will ship with some of Intel's next-generation Core CPUs (codename: Haswell) as well as optional discrete graphics powered by NVIDIA, while others will use powerful new AMD APUs.

HP Pavilion

Mainstream Notebooks

HP unveiled new additions to their bread-and-butter Pavilion lineup: the HP Pavilion 14, HP Pavilion 15, and HP Pavilion 17 notebook PCs. You'll be able to get both AMD and Intel variants, and up to a full terabyte of hard drive space. Given their budget nature, however, don't expect to see anything more than a 1366x768 panel in these guys - even on the 17-inch model (92dpi).

They do come in some pretty attractive colors, though, taking advantage of HP's unique 'imprint' coloring functionality. You'll be able to pick from one of five different colors - black, white, red, blue, and purple.

HP Pavilion

Performance Notebooks

New entries to the ENVY lineup cement the replacement of the old dv line of higher-end consumer notebooks. Like the Pavilions, you'll be able to get both AMD and Intel variants. The ENVY notebooks come with up to 1080p screens and unnamed NVIDIA CPUs. There will be touchscreen variants of the 14- and 15-inch models, sold under the TouchSmart lineup. The 14-inch also qualifies as an Ultrabook under Intel's rules.

While the Pavilion notebooks come with DTS sound, the ENVY models will ship with Beats Audio as part of HP's continuing partnership with the company. On the two larger models, that partnership comes with some extra features: more speakers. While the vast majority of notebooks on the market give you just stereo sound, the ENVY 15 and ENVY 17 will ship with a whopping four speakers and a subwoofer - the ENVY 17's subwoofer is also dual-drive.

11-inch Wonderbooks

Perhaps most excitingly, HP will be offering an all-new replacement for the fantastic dm1 notebook. The big change is that the new Pavilion 11 TouchSmart will ship across the board with a 10-point, multitouch capacitive touchscreen. In fact, a non-touch model isn't even on the books. You'll get partial metal construction, video out ports - basically everything you've come to expect from the dm1 lineup. Plus the touchscreen. That said, don't worry about the touchscreen forcing up the price points - HP is trying to keep things affordable.

High Resolution Options

HP is feeling the heat from competitors like the MacBook Pro with Retina Display and Chromebook Pixel. The ENVY TouchSmart 14 Ultrabook will offer a 3200x1800 resolution display option. That's a whopping 262 pixels per inch, and impressive by any stretch of an imagination.

Free Cloud Storage

All buyers of ENVY notebooks and desktops get a free 50GB cloud storage account from Box.com; Pavilion notebook and desktop buyers will still get 25GB.

Pricing

The Pavillion 11 TouchSmart, despite its specs, will start at just $399 when it ships on June 26th. The Pavilion 14 starts at $479, the Pavilion 15 starts at $429, and the Pavilion 17 starts at $449. All will ship later this year. The HP ENVY 17 starts at $529 and will hit stores on June 5th; the 15 and TouchSmart 15 start at $529 and drop on the same date. Finally, the HP ENVY TouchSmart 14 Ultrabook will start at $699 - though you won't get the 3200x1800 screen for that price; it starts at 1366x768 and will likewise offer a middle 1600x900 option.

Be sure to take a look at all the press images in our gallery of photos!

View the original article here

South Australia's first Apple Store draws line hours ahead of opening [update: photos and video]

South Australia's first Apple Store draws line hours ahead of opening [update: photos and video]Get the lowest prices anywhere on Macs and iPads with exclusive coupons: Apple Price Guide updated May 25th. (Get the lowest prices anywhere)

HomeReviewsBackpagePrice GuidesNew MacsMacs with AppleCarePrevious MacsiPadsApple Wireless DevicesBid on New & Used Apple ProductsFollow UsTwitterFacebookGoogle+RSS Feeds & QriusiPhone AppTip UsSend us a tiptip us anonymouslyContact us by e-mailForumsAAPL: 445.15 ( +3.01 )Never miss an update Follow AppleInsiderFollow @AppleInsider –A+
Friday, May 24, 2013, 05:26 pm

South Australia's first Apple Store draws line hours ahead of opening [update: photos and video]By Mikey Campbell

While Apple's latest retail outlet in Australia isn't scheduled to open for another three hours, customers eager to get into the region's first Apple Store are already queuing up, some having been there for nearly 12 hours.

Adelaide Apple Store

Rundle Place Apple Store in Adelaide. | Source: Reader Jonathan
Pictures from the scene, sent to AppleInsider by reader Jonathan, show about 30 people waiting for the grand opening of Apple's Rundle Place location, the first brick-and-mortar shop the company has set up in South Australia. The first people in line started showing up at 8:30 p.m. last night. Currently, local time in Adelaide is about 7 a.m., well ahead of the scheduled 10 a.m. door opening.

According to Apple's website, the Rundle Place Apple Store will boast a Genius Bar, in-store workshops, One to One service and business-class offerings, as well as free youth programs like Youth Workshops, Field Trips and Apple Camp.

The Adelaide Apple Store will be the first to serve South Australia, saving product owners from traveling to far away cities for repairs and browsing.

Subway

Subway offering free cookies and vouchers to those waiting in line.
A report Monday noted that Apple's brick-and-mortar outlets netted a record $58 per visitor last quarter, which amounted to an average per-store revenue of $13.1 million.

Update: The Rundle Place Apple Store is now open. Following are pictures minutes after doors opened to over 300 people.

Adelaide Apple Store

Apple Geniuses sit next to customers at the Rundle Place Genius Bar.
Adelaide Apple Store

Tags:Apple StoreJump to comments (13)Categories:General(function(d, s, id) { var js, fjs = d.getElementsByTagName(s)[0]; if (d.getElementById(id)) return; js = d.createElement(s); js.id = id; js.src = "//connect.facebook.net/en_US/all.js#xfbml=1"; fjs.parentNode.insertBefore(js, fjs);}(document, 'script', 'facebook-jssdk'));Tweet!function(d,s,id){var js,fjs=d.getElementsByTagName(s)[0];if(!d.getElementById(id)){js=d.createElement(s);js.id=id;js.src="//platform.twitter.com/widgets.js";fjs.parentNode.insertBefore(js,fjs);}}(document,"script","twitter-wjs"); Pin It

On Topic: GeneralFoxconn may sell own branded accessories after Apple profits dipReview: Scosche enters car radio fray with iOS connected controlFREQWorking Apple I fetches $671,400 in German auctionGoogle's Motorola issues second appeal of dismissed ITC case against AppleSouth Australia's first Apple Store draws line hours ahead of opening [update: photos and video]Today's' HeadlinesFoxconn may sell own branded accessories after Apple profits dipApple's iPhone sales tactics in Europe under antitrust investigationRelated ArticlesBriefly: South Australia's first Apple Store to open Saturday in AdelaideApple preps new retail store in Adelaide, AustraliaNew Apple Stores opening in Hong Kong, Australia & Sweden; NJ stores renovatedPhotos from Apple's latest retail openings in US, Australia & ChinaApple's first retail store in Berlin gets May 3 grand openingPrevious Comments View Alllord amhran2013/05/24 06:08pm

Another difference between Microsoft Stores and Apple Stores. You'll never see this kind of devotion & dedication in any place other than an Apple Store

charliepotatoes2013/05/24 06:11pm

Coverse tennis shoes , dirty tee shirts, ripped jeans and scruffy bears are growing old. How about new uniforms with button down shirts, tan khakies, blue blasers and penny loafers for awhile?

taniwha2013/05/24 06:34pm

A store in some small town down under, leaking roofs ... seems that AI has NOTHING to say. Boring

tarfungo2013/05/24 06:56pm

How come this article doesn't indicate which finger poppin', hip-hopping hipster or high profile 'now' band these people are waiting in line for?? The MicroSoft store that recently opened across the mall from my local Apple Store had Kelly Clarkson to attract overnight line squatters? ? \s
?

lord amhran2013/05/24 07:43pm

Quote:Originally Posted by Taniwha?

A store in some small town down under, leaking roofs ... seems that AI has NOTHING to say. BoringNothing of the sort has been reported about this store.

rogifan2013/05/24 07:53pm

Quote:Originally Posted by Taniwha?

A store in some small town down under, leaking roofs ... seems that AI has NOTHING to say. BoringApparently AI isn't allowed or refuses to report stuff from 9to5Mac as they reported new leaked info about iOS 7. A lot more interesting than anything AI reported today.

man-lee2013/05/24 10:09pm

Quote:

Originally Posted by?Taniwha? View Post

A store in some small town down under, leaking roofs ... seems that AI has NOTHING to say. Boring

I'd?barley?describe Adelaide, a State Capital City of over 1.25 mil?people?as?some??"small town". ?Regarding you other comment about "leaking roofs"?maybe?you?had got this story?from another "small town" store in NYC ;) ?Rains once more cause damage at Apple's Fifth Avenue NY store?

http://appleinsider.com/articles/13/05/24/rains-once-more-cause-damage-at-apples-fifth-avenue-ny-store

spacepower2013/05/24 10:42pm

Quote:Originally Posted by CharliePotatoes?

Coverse tennis shoes , dirty tee shirts, ripped jeans and scruffy bears are growing old. How about new uniforms with button down shirts, tan khakies, blue blasers and penny loafers for awhile?

Ssshhhhhh

Microsoft might steal your idea.

ireland2013/05/25 07:36am

God, hate those things. Wuu!!

acslater0172013/05/25 10:14am

Quote:Originally Posted by Taniwha?

A store in some small town down under, leaking roofs ... seems that AI has NOTHING to say. Boring
Maybe you should take your money elsewhere. Oh wait, this is a free website.

View all commentsLogin to Comment

Have an opinion? Sign Up to share it.

Latest Apple Headlines article_thumb